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KMID : 0363320070280030586
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Journal of Korean Oriental Internal Medicine
2007 Volume.28 No. 3 p.586 ~ p.596
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The Neuroprotective Effect of Rhizoma Arisaematis on 3-NP-induced Oxidative Injury of C6 Glial Cells
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Nam Sang-Kyu
Lee Jung-Sup
Shin Yong-Jin
Jeon Ji-Young
Seol Jae-Gyun
Choi Chul-Won
Shin Sun-Ho
Lee In
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Abstract
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Objectives : This study aimed to investigate the underlying protective mechanism of Rhizoma Arisaematis(RA) on 3-NP-induced Cytotoxicity in rat C6 glial cells.
Methods : We investigated treatment ofC6 cells with 20mM 3-NP and pretreatment with RA to cause loss of cell viability. and morphological change. which was associated with elevation of ROS level. increase in Bax/Bcl2 ratio and HIF-a protein expression.
Results : RA inhibited 3-NP-induced cell death in C6 glial cells and inhibited the changes of the : MMPT (mitochondria membrane potential transition) and inhibited the decrease of mitochondria complex II activity and 3-NP-induced ROS generation in C6 cells. And RA decreased the activity of HIF-a and Bax. and increased the activity of Bcl_2 in C6 glial cells.
Conclusions : RA markedly protects C6 glial cells from 3-NP-induced oxidative injury.
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KEYWORD
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Rhizoma Arisaematis, oxidative stress, 3-NP
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